The Frank-Starling Law states that the stroke volume of the heart increases in response to an increase in the volume of blood filling the heart (the end-diastolic volume). At a cellular level, stretching the sarcomeres increases troponin C’s affinity for calcium, maximizing cross-bridge formation.
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Blood flow is governed by physical laws. Pappano utilizes Ohm’s Law ( The Frank-Starling Law states that the stroke volume
Voltage-gated L-type calcium channels open, allowing extracellular calcium ( Ca2+cap C a raised to the 2 plus power ) to enter the cell. : Detailed technical breakdowns of systemic vs
: Detailed technical breakdowns of systemic vs. pulmonary circulation.
The cardiac cycle describes the mechanical and electrical events that occur from the beginning of one heartbeat to the next. Pappano emphasizes the correlation of these events using the Wiggers Diagram, which maps aortic pressure, ventricular pressure, atrial pressure, ventricular volume, and the Electrocardiogram (ECG) over time.
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